XXIV Tropical Medicine Research Center & III International Symposium on Neurogastroenterology and Motility

XXIV Tropical Medicine Research Center & III International Symposium on Neurogastroenterology and Motility

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About

Introduction


The annual meeting in Tropical Medicine and Hygiene & Pharmacology is a regular scientific event, which started in 1996 and now complete its twenty-fourth edition. The event was created to bring together professors, researchers, and students interested in the scientific and technological development of research on tropical diseases that afflict populations in the Brazilian semiarid region. Initially the event was held by effective participation of three national and three international researchers’ groups. The Brazilian groups were led by professors Aldo AM Lima, Federal University of Ceará, Edgar M. Carvalho, Federal University of Bahia, and Selma Jerônimo, Federal University of Rio Grande do Norte. The international groups were led by the researchers, Richard L. Guerrant, University of Virginia, CHO, VA, Warren Johnson, Cornell University, NY, and Lee W. Riley, University of California, Berkeley, CA. The event has covered topics of ongoing research and perspectives in several areas of tropical medicine such as leishmaniasis, leptospirosis, diarrheal diseases, tropical enteropathy, malnutrition, human T-lymphotropic virus (HTLV), human immunodeficiency virus (HIV), leprosy, tuberculosis, among others. The event will be held in Fortaleza, CE, May 5-6, 2020. It is open to the public of researchers, professors, undergraduate and graduate students, as well as technical personnel, receiving annually 40-60 people. The event has contributed to the development of research in tropical medicine and hygiene & pharmacology, sustaining research networks at the regional, national and international levels in areas of interest in public health, especially in the Brazilian semiarid region. In the last seven years, we have the effective participation of two INCTs (Biomedicine- http://www.nubimed.ufc.br and Immunology of Tropical Diseases- inct.cnpq.br/web/inct-dt). The event has been fundamental in the creation of a long-term sustainable research networks (RECODISA: http://www.recodisa.ufc.br; MAL-ED: http://www.upcibimed.ufc.br/MAL-ED) as well as to revigorated the postgraduate degrees in Medical Sciences (Level 6 CAPES), Microbiology (Level 5 CAPES), Pharmacology (Level 6 CAPES) and Morphofunctional Sciences (Level 4 CAPES), as well as demonstrating its importance in national and global public health.

Brief history of previous editions

In the last forty years, initially two national research groups, led by professors Aldo AM Lima and Edgar M. Carvalho, developed important lines of research related to tropical medicine, leishmaniasis and diarrheal diseases & malnutrition, at Universidade Federal do Ceará and Bahia, respectively. Subsequently, a third group led by Professor Selma Jerônimo from the Federal University of Rio Grande do Norte, also emerged in the in leishmaniasis theme. From the beginning, these three research groups have maintained relevant and significant international collaboration with international groups led by researchers, Richard L. Guerrant, Warren Johnson, and Lee W. Riley. The development and progress of these research groups led to the aggregation of new researchers and financial support by national research funding agencies, CNPq and CAPES, as well from abroad, such as the National Institute of Health (NIH), Bethesda, MD, and most recently the Bill and Melinda Gates Foundation. The common environment of research related to tropical medicine led to the formatting of the event, Annual Meeting in Tropical Medicine Research Center & Pharmacology. The first meeting took place in mid-March 1996. Figure 1 illustrates only the researchers participating in the II Annual Meeting of the Tropical Medicine Research Center in Salvador, BA, in March-1997. Note researchers Lee W. Riley (1st from left to right), Aldo AM Lima (3rd), Edgar M Carvalho (6th in the first line), Selma Jerônimo (8th in the first line), Richard Pearson, UVa, CHO, VA (1st. On the second line), and Warren Johnson (2nd. On the second line).


Figure 2 shows the team of speakers, graduate and undergraduate students which attended the XXIII Tropical Medicine Research Center in December 2019. The longevity of this event is based mainly on the regional, national and international interaction and collaboration of researchers interested with lines of research on Tropical Medicine and Hygiene & Pharmacology. This network has engedered a fruitful scientific and technological production, allowing the training of human resources at postgraduate, graduate, and technical level. Over this period were developed two international research agreements between UFBA & University of Cornell and UFC, UFRGN & University of Virginia, which  today constitute international scientific and technological cooperation models for several other national and international institutions. As a result of the promotion of these annual and regular meetings, it was developed two INCTs, Biomedicine and Immunology of Tropical Diseases, and two research networks, RECODISA (www.recodisa.ufc.br) and MAL-ED (www.mal-ed.fnih.org), nationally and internationally. The list of participants in these events and today formed through national and international graduate programs as evidenced in the leaders' CVs lattes, demonstrates the training capacity of human resources that had directly or indirectly promoted these annual and regular meetings of the Tropical Medicine Research Center. Leading researchers were recognized by national and international societies such as the Brazilian Society of Tropical Medicine, the American Society of Tropical Medicine and Hygiene, ASTMH and the Brazilian Academy of Sciences, ABC. The quality of this training can be realized by the fact that the majority, > 80% of graduates, are now researchers and / or professors from national and / or international institutions. It is important to mention that these international collaborations has been essential for the international insertion of our graduate programs. The quality of this academic exchange was recognized by the CAPES, principal Brazilian agency dedicated for the Improvement of Higher Education Personnel, which aproved the project “Internationalization of the Federal University of Ceará in Translational and Epidemiological Research in NeuroGastroenterology”, according the therms of the International Collaboration Program CAPES-PRINT (2018-2022), recently renowned for the next three years. By the way, it allowed to expand the academic exchange of the Federal University of Ceará to the Queen Mary University of London with Prof. Daniel Sifrim, a world-renowned expert on esophageal motility, as well as to the University of Liverpool with Prof. David Criddle, a lecturer on molecular physiology & cell signaling with long-standing interest on calcium and ROS roles in acute pancreatitis.

Due to the Covid-19 pandemic, the event was interrupted. In 2022, the XXIV Tropical Medicine Research Center & Pharmacology and III International Symposium in Neurogastroenterology and Motility will be resumed, this time via Internet, allowing a broader attendance. As one can see in the preliminary program, the event is structured as usual, i.e. with sessions dedicated to major public health problems, with lecture by scholars and oral presentations by graduate students followed by discussion with the audience.

Program

XXIV Tropical Medicine Research Center

PROGRAM

Thursday – 5 Mayth

8:30 - 9:00 am

 

Opening remarks:

José Cândido Lustosa Bittencourt de Albuquerque

Rector, Federal University of Ceará

 

José Glauco Lobo Filho

Vice-Rector, Federal University of Ceará

 

Francisco Rodrigo Porto Cavalcanti

Pro-Rector Researcher and Postgraduation, Federal University of Ceará

 

João Macedo Coelho Filho

Director, Faculty of Medicine, Federal University of Ceará

 

Tarcísio Haroldo Calvacante Pequeno

Presidente da Funcap-CE

 

Aldo Ângelo Moreira Lima

Coordinator, XXIV TMRC & Pharmacology Meeting and Center of Biomedicine, Faculty of Medicine, Federal University of Ceará

 

Armênio Aguiar dos Santos

Coordinator, III International Symposium in Neurogastroenterology and Motility

Center of Biomedicine, Faculty of Medicine, Federal University of Ceará

 

 

Session I:  Environmental enteric dysfunction, enteric infections, and malnutrition.

 Chairpersons: Profs. Aldo AM Lima / Alexandre Havt

 

9:00 - 9:25

Measuring lactulose and mannitol levels to assess environmental enteric dysfunction and malnutrition in children

Lyvia MVC Magalhães, Federal University of Ceará

9:25 - 9:50

Calcium-binding protein Inhibitor attenuates intestinal damage and diarrhea severity during Clostridioides difficile Infection by modulating inflammatory response

Deiziane Viana da Silva Costa, University of Virginia & Federal University of Ceará

9:50 - 10:15

Multi-deficient daily diet causes dynamic changes in the intestinal morphofunctional barrier, body composition and impaired physical development in post-weaning mice

Samilly SA Ribeiro, Federal University of Ceará & Federal University of RGN & University of Virginia

10:15 – 10:40

Break

10:40 - 11:05

 Impact of subclinical enteroaggregative Escherichia coli infection and coinfections on the gastrointestinal epithelial barrier and child growth: a multi-center cohort study

Virginia LSC Urtiga, Federal University of Ceará

 Lunch Break

 Session II:   Nutrition and Metabolomics applied to environmental enteric dysfunction, enteric infections, and malnutrition.

Chairpersons: Profs. Jonathan Swann / Sean R Moore

13:30 - 13:55

Environmental enteric dysfunction, enteric infections, and malnutrition: a role for metagenomic studies

Aldo AM Lima, Federal University of Ceará

 

13:55 -14:20

Redefining enteroaggregative Escherichia coli: a genomic new prospective

Alexandre Havt, Universidade Federal do Ceará

14:20 -14:45

Bile acid profiling reveals distinct signatures in undernourished children with environmental enteric dysfunction

Sean R. Moore, University of Virginia, Charlottesville, VA, USA

14-45 -15:10

Characterizing the biochemical alterations associated with environmental enteric dysfunction using metabolomics

Jonathan Swann, University of Southampton, UK

15:10 – 15:45

Modeling enteropathy or diarrhea with the top bacterial and protozoal pathogens: update on differential determinants of outcomes

Richard L. Guerrant, University of Virginia, Charlottesville, VA, USA

Break

Session III:     Leishmaniasis a common endemic disease: epidemiology, clinical, immunology and genome.

 Chairpersons: Profs. Anastácio de Queiroz Sousa / Selma Jerônimo

 

16:00 -16:25

Leishmaniasis in the semiarid area of Brazil: clinical and epidemiology

Anastácio de Queiroz Sousa, Federal University of Ceará

16:25 - 16:50

Leishmaniasis and coinfections in dogs in the urban community of Fortaleza, Ceará, Brazil

Adam L Lima, Ph.D., Abbott Laboratories and State University of Ceará

16:50 - 17:15

Role of immune-inflammatory biomarkers and pathobiology in leishmaniasis

Selma Jerônimo, Federal University of Rio Grande do Norte

17:15 – 17:40

Colorimetric and fluorometric LAMP for species-specific detection of Leishmania spp.

Rubens Lima do Monte Neto, FIOCRUZ, MG

 

Friday – May 6th

Session IV: SARS-CoV-2 and Influenza A/B virus in human and animal studies

 

Chairpersons: Profs. Eurico Arruda / Roberto J Pires Neto

8:35 – 9:00

A brief look at coronavirus pathogenesis

Eurico Arruda, State Univesity of São Paulo, Ribeirão Preto, SP

9:00 - 9:25

SARS-CoV-2 pathobiology in mild and moderate acute human respiratory infection

Rafhaella Gondim, Federal University of Ceará

9:25- 9:50

N-acetylcysteine: molecular mechanisms of cell preservation against inflammatory aggression of SARS-CoV-2 infection

Hugo Pequeno Monteiro, Escola Paulista de Medicina, UNIFESP, São Paulo, SP

9:50-10:15

Clinical, control, double-blind, randomized trial with N-acetylcysteine  and bromhexine for COVID-19: preliminary results

Roberto J Pires Neto, Federal University of Ceará

10:15-10:40

Intestinal epithelial barrier function and SARS-CoV-2 spike glycoprotein: function and pathobiology using Ussing Chamber model in murine

José Kleybson Sousa, Federal University of Ceará

10:40-11:05

SARS-CoV-2 spike glycoprotein triggers intestinal chloride hypersecretion and inflammation in murine model

Cristhyane Costa de Aquino, Federal University of Ceará

11:05-11:30

Detection of SARS-CoV-2 in different human biofluids using the loop-mediated isothermal amplification assay: a prospective diagnostic study in Fortaleza, Brazil

Marco Clementino, Federal University of Ceará

11:30-11:55

Avian influenza: the new paradigm of H5 viruses

Helena Lage Ferreira, Faculdade de Zootecnia e Engenharia de Alimentos da USP - FZEA/USP, SP, Brasil

11:55 – 12:20

Influenza in pregnancy and childbirth in the Brazilian semiarid: the INFLUEN-SA study

José Quirino Filho, Federal University of Ceará

 

 

III International Symposium on Neurogastroenterology and Motility

 


Friday – May 6th

Neurogastroenterology and motility diseases: nonerosive reflux disease, inflammation, mucosal integrity, and pancreatitis.

 

Chairpersons: Profs. Marcellus P Souza / Armenio A Santos, Federal University of Ceará.

 

13:30 - 13:55

Gastro-esophageal reflux disease: News in pathophysiology and diagnosis

Daniel Sifrim, Queen Mary University of London, UK

13:55 -14:20

Distal esophageal exposure is associated with inspiratory oral pressure, a measurement of the diaphragm strength, particularly in aging

Miguel Ângelo Nobre e Souza, Universidade Federal do Ceará

14:20 -14:45

The role of Ca2+ signaling in the physiology and pathophysiology of exocrine pancreas

David Criddle, University of Liverpool, UK

14-45 -15:00

Impact of the physical exercise on the gastrointestinal dysmotility

Moisés Tolentino Bento da Silva, Universidade do Porto, Portugal

15:00 – 15:15

Activation of the ubiquitin-proteasome pathway in the crural diaphragm in reflux esophagitis 

Suliana Mesquita Paula, Universidade Federal do Ceará

15:15 – 15:40

Role of bile acids in the contractile activity of rat esophageal segments Kaline Kelly Lima Gadelha, Universidade Federal do Ceará

 






Inveted Speakers

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Scientific Committee


Aldo AM Lima, M.D., Ph.D., Federal University of Ceará


Alexandre Havt, Ph.D., Federal University of Ceará


Armênio A Santos, M.D., Ph.D., Federal University of Ceará


Marcellus HLP Souza, M.D., Ph.D., Federal University of Ceará


Pedro JC Magalhães, Ph.D., Federal University of Ceará


Registration

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Contact Us

Communication address to:

R. Cel. Nunes de Melo, 1315, 

Rodolfo Teófilo, Fortaleza - CE, Brazil.

E-mail: nubimed@ufc.br

Phones: 

55-85-3366-8445 

55-85-3366-8437

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